LymphedemaV1, Main, Exploration, bibRecord, 007046

Very Late Antigen (VLA)-1 Blockade Markedly Promotes Survival of Corneal Allografts

Identifieur interne : 007046 ( Main/Exploration ); précédent : 007045; suivant : 007047

Very Late Antigen (VLA)-1 Blockade Markedly Promotes Survival of Corneal Allografts

Auteurs : Lu Chen [États-Unis] ; Syed Huq [États-Unis] ; Humphrey Gardner [États-Unis] ; Antonin R. De Fougerolles [États-Unis] ; Stefano Barabino [États-Unis] ; M. Reza Dana [États-Unis]

Source :

Archives of ophthalmology [ 0003-9950 ] ; 2007.

RBID : PMC:2677688

Abstract

Objective

To investigate the role of very late antigen 1 (VLA-1) (also known as integrin receptor α₁β₁) in corneal transplantation inflammation and allograft survival.

Methods

Cell infiltration and vasculogenesis (both angiogenesis and lymphangiogenesis) associated with allodisparate corneal transplantation were assessed in VLA-1—deficient conditions and controls by immunofluorescent microscopic studies. Corneal allograft survival was also assessed after anti—VLA-1 antibody treatment and in VLA-1 knockout recipient mice.

Results

Anti—VLA-1 antibody treatment leads to a profound reduction in the granulocytic, monocytic, and T-cell infiltration after corneal transplantation. In addition, corneal angiogenesis and lymphangiogenesis were both significantly suppressed in VLA-1 knockout mice. Remarkably, universal graft survival was observed in both anti—VLA-1 antibody treatment and knockout mice.

Conclusions

Very late antigen 1 blockade markedly reduces inflammation and inflammation-induced tissue responses, including vasculogenic responses, associated with corneal transplantation and promotes allograft survival.

Clinical Relevance

These studies offer insights into important integrin-mediated mechanisms of corneal transplant—related inflammation and provide possible new integrin-based immunotherapies for transplant rejection.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677688

DOI: 10.1001/archopht.125.6.783
PubMed: 17562989
PubMed Central: 2677688

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Very Late Antigen (VLA)-1 Blockade Markedly Promotes Survival of Corneal Allografts</title>
<author><name sortKey="Chen, Lu" sort="Chen, Lu" uniqKey="Chen L" first="Lu" last="Chen">Lu Chen</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Immunology, Schepens Eye Research Institute and Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Laboratory of Immunology, Schepens Eye Research Institute and Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Huq, Syed" sort="Huq, Syed" uniqKey="Huq S" first="Syed" last="Huq">Syed Huq</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Immunology, Schepens Eye Research Institute and Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Laboratory of Immunology, Schepens Eye Research Institute and Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gardner, Humphrey" sort="Gardner, Humphrey" uniqKey="Gardner H" first="Humphrey" last="Gardner">Humphrey Gardner</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Research Pathology, Biogen Idec, Cambridge, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Research Pathology, Biogen Idec, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="De Fougerolles, Antonin R" sort="De Fougerolles, Antonin R" uniqKey="De Fougerolles A" first="Antonin R." last="De Fougerolles">Antonin R. De Fougerolles</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Research Pathology, Biogen Idec, Cambridge, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Research Pathology, Biogen Idec, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Barabino, Stefano" sort="Barabino, Stefano" uniqKey="Barabino S" first="Stefano" last="Barabino">Stefano Barabino</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Immunology, Schepens Eye Research Institute and Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Laboratory of Immunology, Schepens Eye Research Institute and Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dana, M Reza" sort="Dana, M Reza" uniqKey="Dana M" first="M. Reza" last="Dana">M. Reza Dana</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Immunology, Schepens Eye Research Institute and Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Laboratory of Immunology, Schepens Eye Research Institute and Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">17562989</idno>
<idno type="pmc">2677688</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677688</idno>
<idno type="RBID">PMC:2677688</idno>
<idno type="doi">10.1001/archopht.125.6.783</idno>
<date when="2007">2007</date>
<idno type="wicri:Area/Pmc/Corpus">002856</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002856</idno>
<idno type="wicri:Area/Pmc/Curation">002855</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002855</idno>
<idno type="wicri:Area/Pmc/Checkpoint">003A45</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003A45</idno>
<idno type="wicri:Area/Ncbi/Merge">002761</idno>
<idno type="wicri:Area/Ncbi/Curation">002761</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002761</idno>
<idno type="wicri:doubleKey">0003-9950:2007:Chen L:very:late:antigen</idno>
<idno type="wicri:Area/Main/Merge">007165</idno>
<idno type="wicri:Area/Main/Curation">007046</idno>
<idno type="wicri:Area/Main/Exploration">007046</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Very Late Antigen (VLA)-1 Blockade Markedly Promotes Survival of Corneal Allografts</title>
<author><name sortKey="Chen, Lu" sort="Chen, Lu" uniqKey="Chen L" first="Lu" last="Chen">Lu Chen</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Immunology, Schepens Eye Research Institute and Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Laboratory of Immunology, Schepens Eye Research Institute and Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Huq, Syed" sort="Huq, Syed" uniqKey="Huq S" first="Syed" last="Huq">Syed Huq</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Immunology, Schepens Eye Research Institute and Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Laboratory of Immunology, Schepens Eye Research Institute and Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gardner, Humphrey" sort="Gardner, Humphrey" uniqKey="Gardner H" first="Humphrey" last="Gardner">Humphrey Gardner</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Research Pathology, Biogen Idec, Cambridge, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Research Pathology, Biogen Idec, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="De Fougerolles, Antonin R" sort="De Fougerolles, Antonin R" uniqKey="De Fougerolles A" first="Antonin R." last="De Fougerolles">Antonin R. De Fougerolles</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Research Pathology, Biogen Idec, Cambridge, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Research Pathology, Biogen Idec, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Barabino, Stefano" sort="Barabino, Stefano" uniqKey="Barabino S" first="Stefano" last="Barabino">Stefano Barabino</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Immunology, Schepens Eye Research Institute and Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Laboratory of Immunology, Schepens Eye Research Institute and Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dana, M Reza" sort="Dana, M Reza" uniqKey="Dana M" first="M. Reza" last="Dana">M. Reza Dana</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Immunology, Schepens Eye Research Institute and Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Laboratory of Immunology, Schepens Eye Research Institute and Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Archives of ophthalmology</title>
<idno type="ISSN">0003-9950</idno>
<idno type="eISSN">1538-3601</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">To investigate the role of very late antigen 1 (VLA-1) (also known as integrin receptor <italic>α</italic>
<sub>1</sub>
β<sub>1</sub>
) in corneal transplantation inflammation and allograft survival.</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods</title>
<p id="P2">Cell infiltration and vasculogenesis (both angiogenesis and lymphangiogenesis) associated with allodisparate corneal transplantation were assessed in VLA-1—deficient conditions and controls by immunofluorescent microscopic studies. Corneal allograft survival was also assessed after anti—VLA-1 antibody treatment and in VLA-1 knockout recipient mice.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Anti—VLA-1 antibody treatment leads to a profound reduction in the granulocytic, monocytic, and T-cell infiltration after corneal transplantation. In addition, corneal angiogenesis and lymphangiogenesis were both significantly suppressed in VLA-1 knockout mice. Remarkably, universal graft survival was observed in both anti—VLA-1 antibody treatment and knockout mice.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Very late antigen 1 blockade markedly reduces inflammation and inflammation-induced tissue responses, including vasculogenic responses, associated with corneal transplantation and promotes allograft survival.</p>
</sec>
<sec id="S5"><title>Clinical Relevance</title>
<p id="P5">These studies offer insights into important integrin-mediated mechanisms of corneal transplant—related inflammation and provide possible new integrin-based immunotherapies for transplant rejection.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Chen, Lu" sort="Chen, Lu" uniqKey="Chen L" first="Lu" last="Chen">Lu Chen</name>
</region>
<name sortKey="Barabino, Stefano" sort="Barabino, Stefano" uniqKey="Barabino S" first="Stefano" last="Barabino">Stefano Barabino</name>
<name sortKey="Dana, M Reza" sort="Dana, M Reza" uniqKey="Dana M" first="M. Reza" last="Dana">M. Reza Dana</name>
<name sortKey="De Fougerolles, Antonin R" sort="De Fougerolles, Antonin R" uniqKey="De Fougerolles A" first="Antonin R." last="De Fougerolles">Antonin R. De Fougerolles</name>
<name sortKey="Gardner, Humphrey" sort="Gardner, Humphrey" uniqKey="Gardner H" first="Humphrey" last="Gardner">Humphrey Gardner</name>
<name sortKey="Huq, Syed" sort="Huq, Syed" uniqKey="Huq S" first="Syed" last="Huq">Syed Huq</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007046 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 007046 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:2677688
   |texte=   Very Late Antigen (VLA)-1 Blockade Markedly Promotes Survival of Corneal Allografts
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:17562989" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

Serveur d'exploration sur le lymphœdème

Very Late Antigen (VLA)-1 Blockade Markedly Promotes Survival of Corneal Allografts

Very Late Antigen (VLA)-1 Blockade Markedly Promotes Survival of Corneal Allografts

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.